12/25/2023 0 Comments Smallest caprineīased on the role of diverse serotypes in human outbreaks, STECs can be categorized into O157 and non-O157 serogroups. At present, some studies have reported the relationship between some subtypes with HC and HUS infections e.g. Overall, there are two primary Shiga toxins (Stx1 and Stx2), and each of them is divided into different subtypes. Also, some characteristics like serotypes and phylo-types can be regarded as indicators of pathogenic STECs. The pathogenic potential of STEC strains can be attributed to various factors, such as virulence genes and Shiga toxin subtypes. STECs are found in humans and a wide range of warm blooded animals, but ruminants have been proven as the main source of food contamination and the major reservoirs for human infections. This is because they are known as foodborne pathogens and are responsible for the sporadic and epidemic incidence of hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS), worldwide. Shiga toxin-producing Escherichia coli (STEC) are among the most challenging microorganisms of public health concern. Conclusionsĭespite the fact that the top 8 STEC serogroups were uncommon in caprine strains, the presence of highly pathogenic stx subtypes indicates that small ruminants and their products can be considered as an overlooked public health risk for humans, especially in developing countries which consume traditional products. STEC strains showed a substantial diversity in DNA fingerprinting there were 24 unique ERIC-types (with a ≥95% similarity) among the isolates. In phylo-typing the isolates mostly belonged to phylo-group B1 (82.4%), followed by phylo-group A (12.3%). Interestingly, none of stx + eae + isolates belonged to the tested serogroups. In serogrouping, the majority of STECs from goats did not belong to the top 8 serogroups but two strains belonged to O113, which has been recognized as an important pathogenic STEC in Australia. The stx subtypes predominantly occurred in four combinations, including stx1a/stx1c (35%), stx1c (31.5%), stx1c/stx2a/stx2c/stx2d (5.2%) and stx1c/stx2c/stx2d (%5.2%). In some parts of the world, these subtypes have been reported in relation with severe human infections. Three (5.2%) isolates were characterized as EHEC, which carried both eae and stx genes. 24.5% P ≤ 0.05), and 22.8% of strains harbored both stx1 and stx2 genes. ResultsĪmongst 57 STEC strains isolated from goats, the prevalence of stx1 was significantly more than stx2 (98.2% vs. In this study, a total of 57 STEC strains were recovered from 450 goats and characterized by subtyping of stx genes, O-serogrouping, phylo-typing and DNA fingerprinting. The objective of this research was to investigate the pathogenic potential of the STEC strains isolated from slaughtered goats. Ruminants, especially cattle are the main reservoirs but the role of small ruminants in the epidemiology of human infections has not been thoroughly assessed in many countries. Eight serogroups have the greatest role in the outbreaks and diseases caused by STEC which include O26, O45, O103, O111, O113, O121, O145 and O157. All over the world, Shiga toxin-producing Escherichia coli (STEC) are considered as important zoonotic pathogens.
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